OmicScouts' technologies enable informed decisions at different stages of the drug discovery process. Generally, our technologies support both traditional, target-based drug discovery and phenotypic, chemical genetics-based drug discovery.
- The chemical proteomics TargetScout™ technology and proteome-wide CETSA® MS reveal and verify specific cellular targets, determine target-specific dissociation constants in a physiological setting, and provide selectivity information and on-/off-target liabilities
- ProteomeScout™ provides a quantitative in-depth view of the proteome and supports the identification and selection of potential drug targets, PD and drug response biomarkers
- Proteome-wide, quantitative profiling of post-translational modifications such as phosphorylation, ubiquitinylation or acetylation using the SignallingScout™ technology reveals target engagement information and on-/off-pathway liabilities
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Bunnage, M.E., Gilbert, A.M., Jones, L.H., Hett, E.C. (2015) Know your target, know your molecule, Nat Chem Biol. 11(6):368-72. [Link]
Schirle, M., Bantscheff, M., and Kuster, B. (2012). Mass Spectrometry-based Proteomics in Preclinical Drug Discovery, Chem Biol 19(1):72-84. [Link]